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The newest pheomelanin ring on the agouti-designed hairs is caused by a heart circulation of ASIP expression throughout the hair regrowth, causing a switch of eumelanin in order to pheomelanin production. To find the aftereffect of p.H587Y on the CORIN’s reason for controlling ASIP in the tiger, we transfected HEK293 tissues having tiger ASIP and you can/otherwise CORIN variations. No distinction is thought of between your expression level of insane-type of CORIN plus the p.H587Y mutant within the cells (Figure 1F, leftover panel).
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